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Analysis of expression profile of APC in pterygium

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Year: 2014
COI code: CIGS13_1154
Paper Language: English

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Authors Analysis of expression profile of APC in pterygium

  Maryam Najafi - Departement of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
  Dor mohammmad Kordi Tamandani - Departement of Biology, University of Sistan and Baluchestan, Zahedan, Iran.
  Mohammad Arish - Department of Ophthalmology, Al-Zahra Eye Hospital, Zahedan University of Medical Sciences, Zahedan, Iran
  Robab Poyandeh - Departement of Biology, University of Sistan and Baluchestan, Zahedan, Iran.

Abstract:

Background: Pterygium is a fairly general condition in many hot regions of the world. The etiology of this abnormality is still ambiguous. However, recent findings suggest that pterygium is a benign progressive tissue and not a degenerative disorder. The main goal of our study was the analyze of APC expression profile on therisk of pterygium. Material and methods: In this study, the RNA of 20 primary pterygium and 20 normal conjunctiva tissues were extractedand modified for preparing the cDNA. We estimated the mRNA expression levels of these genes in pterygium and normalconjunctiva tissue samples using real-time quantitative reverse transcriptase PCR. Results: we detected a decreased expression of the APC gene in pterygium but it was not significant. Conclusion: Our results indicated that reduced expression of APC gene have taken place in patients with the pterygium. To confirm the presented data, suggesting further studies with a larger sample size in various genetic populations.

Keywords:

APC, Real time, mRNA expression

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COI code: CIGS13_1154

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Najafi, Maryam; Dor mohammmad Kordi Tamandani; Mohammad Arish & Robab Poyandeh, 2014, Analysis of expression profile of APC in pterygium, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_1154.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Najafi, Maryam; Dor mohammmad Kordi Tamandani; Mohammad Arish & Robab Poyandeh, 2014)
Second and more: (Najafi; Kordi Tamandani; Arish & Poyandeh, 2014)
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Type: state university
Paper No.: 9184
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