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Comparing Developmental Competence of mature and immature oocyte in PCOs patients and mRNA levels of AMHR gene as biomarker

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Year: 2018
COI code: CIGS15_393
Paper Language: English

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Authors Comparing Developmental Competence of mature and immature oocyte in PCOs patients and mRNA levels of AMHR gene as biomarker

  Fateme Montazer - Department of Biology, Faculty of Science, Chamran University of Ahvaz, Ahvaz, Iran. Recurrent Abortion Research Center, Yazd reproductive sciences institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
Ali Mohammad Foroughmand - Department of Biology, Faculty of Science, Chamran University of Ahvaz, Ahvaz, Iran
  Seyed Mehdi kalantar - Yazd reproductive sciences institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran;
  Abbas Aflatoonian - Yazd reproductive sciences institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran;
  Mohammad Ali Khalilli - Yazd reproductive sciences institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran;
  Farzaneh Fesahat - Recurrent Abortion Research Center, Yazd reproductive sciences institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

Abstract:

Background: In vitro maturation (IVM) could be a good choice for patients who are hormone sensitive and have few oocytes in stimulated cycles. Consequently, selecting embryos with the highest implantation potential is of great importance in assisted reproductive technologies (ART). To date, the choice of the best embryos to transfer is based on morphological parameters. Therefore, movement towards modern technologies such as genomics, transcriptomics, proteomics and metabolomics to select the most competent oocytes and/or embryos with the greatest implantation potential would be significant.Objective: The aim was to assess the developmental competence of the in vitro and in vivo matured human oocytes as well as the AMHR gene expression of cumulus cells (CCs) between tow group in order to evaluate oocyte maturity in PCOs patient.Material and Method: The oocytes and the associated CCs were retrieved from 27 PCO women and divided into groups of GV and MII according to the nuclear maturity status in order to studding developmental competence as well as expression patterns of AMHR gene using real time PCR.Result and conclusion: The fertilization and embryo formation rates were 61.5% and 84.5% vs.67.1% and 90.8% in test and control groups, respectively. There were significant differences in mRNA levels of AMHR gene between the groups. It seems that using immature oocytes could be helpful for patients at risk of ovarian hyperstimulation syndrome (OHSS) as the same as patients with diminished ovarian reserve.

Keywords:

Polycystic Ovarian Syndrome (PCOs), In vitro Maturation (IVM), Oocyte maturity, Embryo selection, AMHR gene, Biomarker

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COI code: CIGS15_393

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Montazer, Fateme; Ali Mohammad Foroughmand; Seyed Mehdi kalantar; Abbas Aflatoonian; Mohammad Ali Khalilli & Farzaneh Fesahat, 2018, Comparing Developmental Competence of mature and immature oocyte in PCOs patients and mRNA levels of AMHR gene as biomarker, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_393.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Montazer, Fateme; Ali Mohammad Foroughmand; Seyed Mehdi kalantar; Abbas Aflatoonian; Mohammad Ali Khalilli & Farzaneh Fesahat, 2018)
Second and more: (Montazer; Foroughmand; kalantar; Aflatoonian; Khalilli & Fesahat, 2018)
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Type: Medical University
Paper No.: 1949
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