COI code: CIGS15_518
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Bone tissue engineering using Zein/HA nanocomposite scaffoldFataneh Rastgoo - Department of biology, Faculty of Science, University of Guilan, Rasht, Iran
Zivar Salehi - Department of biology, Faculty of Science, University of Guilan, Rasht, Iran
S.Shirin Shahangian - Department of biology, Faculty of Science, University of Guilan, Rasht, Iran
Mahvash Hadavi - Department of biology, Faculty of Science, University of Guilan, Rasht, Iran
Abstract:Tissue engineering is basically a Biomimetic technique for tissue regeneration. Natural tissues consist of three components: cells, signaling systems (e.g. growth factors) and extracellular matrix (ECM). The ECM forms a scaffold for its cells. A huge effort has been invested in bone tissue engineering, in which a highly porous scaffold plays a critical role in guiding bone and vascular tissue growth and regeneration in three dimensional positions. The selection and design of a bone matrix-like biomaterial are primarily determined by the composition of the osseous tissue. Bone is composed of hydroxyapatite and osteocalcium phosphate as mineral components and collagen, proteoglycans, matrix proteins, cytokines and growth factors as organics. In present study, a composite of zein and HA was fabricated with salt-leaching method and characterized with SEM and FTIR. SEM images were analyzed with imageJ software for scaffold pore size distribution and wall thickness assessment. NIH3T3 mouse embryonic fibroblast cell was used as a model system. Cell adhesion and proliferation was evaluated with MTT assay. The results showed that Zein/HA nanocomposite was a biocompatible material for NIH3T3 and cells morphology was favorable on scaffold surface. The pores are open and appeared randomly distributed in SEM images. The mean pore size was 291/25 μm and 306.55 μm in zein and zein/HA scaffolds respectively. For detection of NIH3T3 cell response to Zein/HA scaffold condition, osteogenic marker genes (such as ALP) expression will quantify with qRT-PCR in the future.
Keywords:Zein/HA; scaffold; NIH3T3; ALP; Bone tissue engineering
COI code: CIGS15_518
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Rastgoo, Fataneh; Zivar Salehi; S.Shirin Shahangian & Mahvash Hadavi, 2018, Bone tissue engineering using Zein/HA nanocomposite scaffold, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_518.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Rastgoo, Fataneh; Zivar Salehi; S.Shirin Shahangian & Mahvash Hadavi, 2018)
Second and more: (Rastgoo; Salehi; Shahangian & Hadavi, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: state university
Paper No.: 11373
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Study of genetic variation in chickpea (Cicer arietinum L.) genotypes based on ISSR markers and evaluation of resistance to Fusarium wilt
- Characterization of stem cells isolated from peritoneal dialysed fluid
- Association between genetic polymorphism of catalase (CAT) C-262T, Cu/Zn superoxide dismutase (SOD1) A251G and risk of Age-related macular degeneration (AMD)
- Regional variation in subclade of Leptosphaeria biglobosa
- Genetic study of external egg quality traits of native chicken of North of Iran
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.