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A comparison of liquid-based cytology with conventional Papanicolaou smears in cervical dysplasia diagnosis

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Year: 2019
COI code: DTOGIMED03_131
Paper Language: English

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Authors A comparison of liquid-based cytology with conventional Papanicolaou smears in cervical dysplasia diagnosis

  Nahid Ghanbarzadeh - gynecology department birjand university of medical scince
  Nahid Ghanbarzadeh - tehran university of medical scince


Background and Aim : Due to the high number of women affected by cervical cancer and the importanceof an early diagnosis, combined with the frequent incidence of false-negative Papanicolaou (Pap) smearscreening results for this disease, several studies have been conducted in recent years in order to find bettertests. Liquid-based cytology (LBC) tests, including the liquid-based thin layer method, have demonstratedthe highest potential for reducing false-negative cases and improved sample quality. This study aimed tocompare the strength of the Pap smear test with fluid cytology and conventional tests in detecting cervicaldysplasia.Methods : This descriptive-analytic study was conducted on 366 women who attended private laboratoriesfor a Pap smear. The Pap smear sampling was conducted simultaneously using two methods: conventionalPap (CP) smear and LBC), from the cervix.Results : The mean age of the participants was 32 ± 8.8 years. Diagnostic results of endocervical cells,epithelial cells, vaginitis cells, and metaplastia were consistent with both conventional and liquid cytologysmears, and the kappa coefficient was determined to be significant (P < 0.001). In total, 40.5% of diagnosticcases indicated bacterial inflammation 80.3% of the diagnoses in both methods were P1 and 3.9% of casesdiagnosed were P2, the overall diagnostic consistency was 83.9% between the two sampling methods. Theinflammation diagnosis was 40.5% and this was consistent in both methods of LBC and CP. There was onecase of a false-negative diagnosis in the LBC method and 14 cases in the CP method.Conclusion : Results showed that the LBC may improve the sample s quality and reduce the number ofunsatisfactory cases more than with the CP method.


Cervical dysplasia, liquid-based cytology, Papanicolaou smears examination

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COI code: DTOGIMED03_131

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Ghanbarzadeh, Nahid & Nahid Ghanbarzadeh, 2019, A comparison of liquid-based cytology with conventional Papanicolaou smears in cervical dysplasia diagnosis, 3rd debatable topics on obstetrics gynecology & infertility, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي و درماني شهيد بهشتي, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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The University/Research Center Information:
Type: Medical University
Paper No.: 724
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