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Effects of Dehydroepiandrosterone on the Response of Ovarian Stimulation During In Vitro Fertilization Cycle in Infertile Women With Diminished Ovarian Reserve: Before and After Clinical Trials

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Year: 2019
COI code: DTOGIMED03_225
Paper Language: English

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Authors Effects of Dehydroepiandrosterone on the Response of Ovarian Stimulation During In Vitro Fertilization Cycle in Infertile Women With Diminished Ovarian Reserve: Before and After Clinical Trials

  Marzieh Zamaniyan - Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  Bahar Farshidfar - Student Research Committee, College of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  Sepideh Peyvandi - Infertility Center, Department of Obstetrics and Gynecology, Mazandaran University of Medical Sciences, Sari, Iran

Abstract:

Background and Aim : The use of dehydroepiandrosterone (DHEA) before initiating in vitro fertilization(IVF) cycles to increase the ovarian reserve is considered as one of the best therapies in women withdiminished ovarian reserve (DOR). Therefore, the present study aimed to compare the effect of DHEA onwomen (below and above 35 years old) with DOR and to find if this therapy is useful at an earlier age.Methods : This clinical trial study was conducted on 35 infertile women with DOR who referred to ImamKhomeini hospital in Sari, Iran, during 2017. The intervention lasted for 6 weeks and DHEA tablets wereused before the start of the intra-cytoplasmic sperm injection-embryo transfer (ICSI-ET) cycle. Antralfollicular counts (AFCs) and the serum levels of anti-Mullerian hormone (AMH) were estimated beforeand after the intervention, followed by performing the ICSI. Finally, the changes in AMH levels and AFC,the number and quality of ovum and embryos and pregnancy, along with the rates of implantation andabortion were measured as well.Results : The mean AMH levels (P = 0.02) and AFC (P < 0.001) after DHEA consumption variedsignificantly from those before administering the DHEA, and the increase in the AFC was more significantin the age group under 35 years (P = 0.03). In addition, these changes were more significant in body massof less than 25 kg/m2 (P = 0.04).Conclusion : In general, the supplementation of DHEA in women with insufficient ovarian capacityprobably improves IVF prognosis and other parameters including AFC and AMH, especially in womenunder 35 years old. Further, based on different evidence, the probability of pregnancy occurrence in womenis lower with increased body mass index (BMI).

Keywords:

Dehydroepiandrosterone, Ovarian reserve, Anti-Mullerian Hormone, Infertility

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COI code: DTOGIMED03_225

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Zamaniyan, Marzieh; Bahar Farshidfar & Sepideh Peyvandi, 2019, Effects of Dehydroepiandrosterone on the Response of Ovarian Stimulation During In Vitro Fertilization Cycle in Infertile Women With Diminished Ovarian Reserve: Before and After Clinical Trials, 3rd debatable topics on obstetrics gynecology & infertility, تهران, دانشگاه علوم پزشكي و خدمات بهداشتي و درماني شهيد بهشتي, https://www.civilica.com/Paper-DTOGIMED03-DTOGIMED03_225.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Zamaniyan, Marzieh; Bahar Farshidfar & Sepideh Peyvandi, 2019)
Second and more: (Zamaniyan; Farshidfar & Peyvandi, 2019)
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Type: Medical University
Paper No.: 1674
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