Association between mir-143 rs4705342 polymorphism and risk of recurrence in breast cancer patients

Introduction & Aim: The recurrence of breast cancer (BC) is a major cause of cancer death in females. miR-143 plays roles in antitumor activities by inhibiting proliferation, and cell invasion and migration. The aim of our study was to examine association of the miR-143 rs4705342 with the recurrence of BC.Methods: The present study was done on 424 females with BC (102 patients with the recurrence of BC, as the case group, and 322 women without any recurrence of BC, as the control group). After DNA extraction from peripheral blood, genotype determination was done using Tetra ARMS PCR Technique. Thereafter, the genotype and allele frequency of miR-143 rs4705342 was compared between the two groups. Results: The results were shown that TC (OR=3.737; P=0.001) genotype and C (OR=3.189; P=0.001) allele of miR-143 rs4705342 are associated with BC recurrence. Conclusion: Thus, miR-143 rs4705342 polymorphism is associated with the susceptibility of BC recurrence.

Keywords:

Breast Cancer Recurrence , miR-143 , Polymorphism , micro RNA