CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings

Early detection of breast cancer using circulating miRNAs in peripheral blood

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 113
Year: 2018
Present: شفاهي
COI code: ICBCMED14_110
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Early detection of breast cancer using circulating miRNAs in peripheral blood

  Marzieh Ahmadi - Department of Genetics, University of Science and Culture, ACECR, Tehran, Iran.
  Hanieh Sadeghi - Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Aryan Kamal - Department of Clinical Bioinformatics, Saarland University, Saarbr¨ ucken, Germany.
  Mehdi Totonchi - Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.


Introduction & Aim: The routine screening for breast cancer (BC) depends primarily on imaging techniques such as mammography, although it is not often sensitive enough for early detection and requires complementary approaches. The discovery of microRNAs (miRNA) has opened a new window for tumor diagnosis. miRNAs are a class of small noncoding RNAs that control gene expression by targeting mRNAs. The aberrant expression is involved in human disease, including breast cancer. The aim of this study was to identify novel biomarkers of circulating miRNAs for detecting BC in early stages. Methods: we analyzed the data of miRNAs expression related to 778 patients diagnosed with breast cancer and, 87 control samples, and 5239 healthy and unhealthy samples regarding 13 different types of cancer from The Cancer Genome Atlas (TCGA) database. Twenty-two candidate miRNAs were identified that could distinguish individuals with breast cancer from normal ones based on two bioinformatics approaches: Machin learning and deferentially expression. We used quantitative real-time polymerase chain reaction (qRT-PCR) to validate miRNAs expression levels, in whole blood samples from 71 breast cancer patients and 61 healthy controls. Results: We demonstrated that seven miRNAs could be used as potential biomarker to detect breast cancer in early stages. Conclusion: These findings suggest that assessment of miRNAs in blood samples can be applied as minimally non-invasive markers for early detection of breast cancer.


Breast cancer, Early detection, miRNA, Biomarker

Perma Link
COI code: ICBCMED14_110

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Ahmadi, Marzieh; Hanieh Sadeghi; Aryan Kamal & Mehdi Totonchi, 2018, Early detection of breast cancer using circulating miRNAs in peripheral blood, 14th International Congress on Breast Cancer, تهران, مركز تحقيقات سرطان دانشگاه علوم پزشكي شهيد بهشتي, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ahmadi, Marzieh; Hanieh Sadeghi; Aryan Kamal & Mehdi Totonchi, 2018)
Second and more: (Ahmadi; Sadeghi; Kamal & Totonchi, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)


The University/Research Center Information:
Type: Nonprofit Institute
Paper No.: 1138
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper


COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.