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The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population

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Year: 2016
COI code: IPMCMED01_122
Paper Language: English

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Authors The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population

Zahra Rezakazemi - Damghanazad university, Damghan, Iran
Malihe Khiabani - Damghanazad university, Damghan, Iran
Masoome Rahmani - Damghanazad university, Damghan, Iran
Leila Akbari - Taban clinic, Tehran, Iran


Cytochrome P450 1A2 (CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene, CYP1A2, a hepatic enzyme inducible by smoking, metabolizes various chemical procarcinogens, such as food-derived heterocyclic and aromatic mutagens, N-heterocyclics found in tobacco smoke, and difuranocoumarins, to reactive carcinogens.there are many epidemiological reports examining the role of variant CYP1A2, metabolism of procarcinogens and cancer risk. The enzyme has a significant role in chemical carcinogenesis and is induced by its substrates. CYP1A2*1K, rs762551:C > A plus rs2069526:T > G, and rs12720461:C > T showed decreased metabolism Subjects with CYP1A2*1K hadsignificantly decreased CYP1A2 activity in vivo, and reporter constructs with this haplotype had significantly less inducibility with 2,3,7,8-tetrachlorodibenzo-p-dioxin. CYP1A2*1K polymorphism is decreased the effect of drugs in human ovarian carcinoma cell.


Gastric cancer; Bioinformatics; miRNA; Metastasis; Stemness; Drug Resistance

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COI code: IPMCMED01_122

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Rezakazemi, Zahra; Malihe Khiabani; Masoome Rahmani & Leila Akbari, 2016, The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Rezakazemi, Zahra; Malihe Khiabani; Masoome Rahmani & Leila Akbari, 2016)
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