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The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population

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Year: 2016
COI code: IPMCMED01_122
Paper Language: English

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Authors The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population

Zahra Rezakazemi - Damghanazad university, Damghan, Iran
Malihe Khiabani - Damghanazad university, Damghan, Iran
Masoome Rahmani - Damghanazad university, Damghan, Iran
Leila Akbari - Taban clinic, Tehran, Iran

Abstract:

Cytochrome P450 1A2 (CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. In humans, the CYP1A2 enzyme is encoded by the CYP1A2 gene, CYP1A2, a hepatic enzyme inducible by smoking, metabolizes various chemical procarcinogens, such as food-derived heterocyclic and aromatic mutagens, N-heterocyclics found in tobacco smoke, and difuranocoumarins, to reactive carcinogens.there are many epidemiological reports examining the role of variant CYP1A2, metabolism of procarcinogens and cancer risk. The enzyme has a significant role in chemical carcinogenesis and is induced by its substrates. CYP1A2*1K, rs762551:C > A plus rs2069526:T > G, and rs12720461:C > T showed decreased metabolism Subjects with CYP1A2*1K hadsignificantly decreased CYP1A2 activity in vivo, and reporter constructs with this haplotype had significantly less inducibility with 2,3,7,8-tetrachlorodibenzo-p-dioxin. CYP1A2*1K polymorphism is decreased the effect of drugs in human ovarian carcinoma cell.

Keywords:

Gastric cancer; Bioinformatics; miRNA; Metastasis; Stemness; Drug Resistance

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COI code: IPMCMED01_122

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Rezakazemi, Zahra; Malihe Khiabani; Masoome Rahmani & Leila Akbari, 2016, The Prevalence of CYP1A2*1k polymorphism in different ethnics of Iranian population, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_122.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Rezakazemi, Zahra; Malihe Khiabani; Masoome Rahmani & Leila Akbari, 2016)
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