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Genotyping and expression study of NRG1 in schizophrenic patients have presented biomarkers for negative symptoms

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Year: 2016
COI code: IPMCMED01_133
Paper Language: English

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Authors Genotyping and expression study of NRG1 in schizophrenic patients have presented biomarkers for negative symptoms

  Zahra Sadat Hosseini - faculty of biological science,kharazmi university,karaj,iran
  Mohammad Tahmaseb - faculty of biological science,kharazmi university,karaj,iran
Sahel Hemmati - Pediatric neurohabilitation research center, social welfare and rehabilitation sciences university, Tehran, Iran
Arvin Haghighatfard - Department of biology, Tehran North branch, Islamic Azad University, Tehran, Iran

Abstract:

Schizophrenia (SCZ) is a complex psychiatric disorder with no clarified etiology or biological diagnosis. Most common symptoms of schizophrenia are positive, negative and cognitive. Neurodevelopmental deficiencies have been suggested as one of the possible reasons of schizophrenia. Neuregulin1 (NRG1) gene-located at 8p12- is an epidermal growth factor which is essential for normal development of central nervous system. NRG1 has several isoforms that could be grouped in six type based on their functions. Type I, II and III of NRG1 are expressed in excitatory and inhibitory neurons, as well as astrocytes and are involved in regulation of neuronal activity.Prevalence of 13 most common single nucleotide polymorphisms of NRG1 in psychosis along with mRNA level of types I, II and III in this gene were studied in blood samples of 190 Iranian schizophrenic patients and 150 non-psychiatric subjects using quantitative Real time PCR. Also positive and negative symptom scale (PANSS) and brief psychiatric rating scale (BPRS) from patients and Wechsler Adult Intelligence Scale (WAISE) from all subjects were obtained.Presence of rs2954041, rs3924999 and rs6994992 were significantly associated (pResults have confirmed role of NRG1 in schizophrenia. Findings showed down regulation of types I, II and III of NRG1 in schizophrenia which were significantly related to lack of emotional and executive functions and could be a marker of low neural activity in schizophrenic brain. In addition rs3924999 have presented as marker for down expression of NRG1 and a potential peripheral marker for negative symptoms of schizophrenia.

Keywords:

NRG1 - schizophrenia - gene expression - rs3924999

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COI code: IPMCMED01_133

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Hosseini, Zahra Sadat; Mohammad Tahmaseb; Sahel Hemmati & Arvin Haghighatfard, 2016, Genotyping and expression study of NRG1 in schizophrenic patients have presented biomarkers for negative symptoms, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_133.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Hosseini, Zahra Sadat; Mohammad Tahmaseb; Sahel Hemmati & Arvin Haghighatfard, 2016)
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Paper No.: 9273
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