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Association of G22A polymorphism of adenosine Deaminas with obesity in an Iranian population

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Year: 2016
COI code: IPMCMED01_166
Paper Language: English

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Authors Association of G22A polymorphism of adenosine Deaminas with obesity in an Iranian population

  Sepideh Borhan - Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  Samaneh Sadat Enayati - Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  Mahsa Mohammad Amoli - Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Abstract:

Obesity is an important clinical and public health challenge and defined as an excess adipose tissue accumulation resulting from an imbalance in energy intake and energy expenditure. It is a forerunner for a variety of other disease such as type-2-diabetes, cardiovascular disease and can be fatal leading to premature death. Obesity is highly heritable and arises from the interplay of multiple genes and environmental factors. Adenosine deaminase, a key enzyme in purine metabolism, regulates extracellular and intracellular concentrations of adenosine by irreversible deamination of adenosine into inosine. ADA, present in all mammalian cells and its primary function in humans is development, differentiation, and maturation of the lymphoid system. ADA is encoded by the polymorphic ADA gene, which is located on chromosome 20q13.11. One of the commonest single nucleotide polymorphisms of ADA gene is the SNP G22A in exon1. This SNP results in the substitution of Asp amino acid (G allele) with Asn (A allele) amino acid in position 8 of the enzyme. The aim of the present study was to investigate the association between SNP G22A in the ADA gene with the obesity.

Keywords:

obesity, adenosine deaminas (ADA), G22A polymprphism

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COI code: IPMCMED01_166

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Borhan, Sepideh; Samaneh Sadat Enayati & Mahsa Mohammad Amoli, 2016, Association of G22A polymorphism of adenosine Deaminas with obesity in an Iranian population, First Personal Medical Congress, تهران, دانشگاه علوم پزشكي ايران - پژوهشكده ملي مهندسي ژنتيك و زيست فناوري ايران، مركز همكاري هاي فناوري و نوآوري هاي رياست جمهوري, https://www.civilica.com/Paper-IPMCMED01-IPMCMED01_166.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Borhan, Sepideh; Samaneh Sadat Enayati & Mahsa Mohammad Amoli, 2016)
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Type: Medical University
Paper No.: 6375
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