Interaction between obesity-related MC4R (Rs17782313) gene, associated to an increase of Breast Cancer risk.

Background: Breast cancer (BC) is a complex disease and obesity is a well-known risk factor for its development, especially after menopause. Several studies have shown singe nucleotide polymorphism (SNP) linked to overweight and obesity, such as: rs17782313 (T/C) in Melanocortin 4 Receptor gene (MC4R). Thus, we aimed to investigate the association between these obesity-related SNP and BC risk. Methods: Genomic DNA was extracted from peripheral blood of 63 breast cancer patients and 83 normal controls. Height and weight were measured to calculate body mass index (BMI). All were genotyped for the SNPs rs17782313 using a Tetra-primer ARMS-PCR method. For statistical analysis P-value test and SPSS software were used. Results: In this study, two Odds Ratio and P-value factors were investigated. Our research has shown those who have cancer and are overweight cause a significant increase in breast cancer (P-value> 0.005).but those who are obese are the result of a reverse. Conclusion: To our knowledge, the present meta-analysis suggested that only there might be a significant association of the MC4R Rs17782313 polymorphism with breast cancer risk. The basis of our research we suggest that further functional may elucidate the role of genomic variation in breast cancer development.

Keywords:

Breast Cancer , MC4R , Obesity , Polymorphism