A Green and Efficient Synthesis of 2-Thioxoquinazolinone Derivatives in Water Using Potassium Thiocyanate

Green chemistry is one of the most important routes for the synthesis of heterocyclic compounds. In this regard, the synthesis of 2-thioxoquinazolinone derivatives was achieved by condensation of versatile materials including isatoic anhydride, amine, and potassium thiocyanate in green medium of water. This convenient and efficient method affords the desired products with good to excellent yields.In this regard, new procedures were designed by chemists to reduce the environmental pollutions and to save energy [1]. Optimizing the reaction conditions in the presence of environmental friendly solvents (e.g. water and ethanol) instead of toxic solvents is noticeable for green synthesis of organic compounds especially heterocycles [2]. Although there are several methods for the synthesis of entitled heterocycles, but due to the importance of introducing green methods for the preparation of heterocycles in organic synthesis, the present methodology can be regarded as a versatile strategy for the synthesis of 2-thioxoquinazolinone derivatives. Considering the fact that most 2-thioxoquinazolinone derivatives show interesting biological activities, the new compounds synthesized in this paper are valuable for further pharmaceutical research.