Synthesis of polycaprolactone-diols by ring opening polymerization as biocompatible and biodegradable polymers

Ring opening polymerization of ε-caprolactone was carried out at 130 °C, under partial vacuum in the presence of stannous octoate as the catalyst and 1, 4-Butanediol as the initiator. After the termination of polymerization by deionized water, a hydroxyl group formed at the end of the polymer chains. Structure of the synthetic poly (ε-caprolactone)-Diols (PCL-Diol), molecular weight, polydispersity index (PDI) and Cell viability evaluated. Very narrow distribution in the molecular weight obtained for PCL-Diols is due to a new method for synthesis. It was shown that by the increase of PCL-Diols, the compatibility of human mesenchymal stem cells grew up