Effect of Systemic Granisetron in the Clinical Course of Spinal Anesthesia with Hyperbaric Bupivacaine for Outpatient Cystoscopy

Background: The goals of this study are evaluation the effect of intravenous (IV) granisetron on the durationof sensory and motor block produced by intrathecal hyperbaric bupivacaine and also post-operative nausea andvomiting in patients undergoing outpatient cystoscopy.Methods: 62 patients, undergoing cystoscopy received either 3 mg IV granisetron or placebo 15 minutesbefore the spinal block. Sensory and motor block were assessed after the intrathecal injection of bupivacaineevery 2 minutes until the maximum block was achieved and thereafter every 15 minutes until recovery fromthe sensory and motor block.Results: Demographic data were not statistically different in the study groups. Duration of sensory and motorblock were also not statistically different between the study groups (P = 0.060 and P = 0.070 respectively). Nopatient in either group had vomiting. Seven patients in saline and zero patient in granisetron group had nauseathat was statistically significant (P = 0.040). Time to discharge after surgery was 243 ± 21 and 239 ± 24minutes in granisetron and control group respectively (P = 0.150).Conclusions: Systemic granisetron had no effect on the duration of sensory and motor block produced byspinal anesthesia with hyperbaric bupivacaine.© 2015 Tehran University of Medical Sciences. All rights reserved.Citation: Soltani-Mohammadi S, Esmaeili S, Saliminia A. Effect of Systemic Granisetron in the ClinicalCourse of Spinal Anesthesia with Hyperbaric Bupivacaine for Outpatient Cystoscopy. Acad J Surg, 2015;2(1-2): 18-22.

Keywords:

Bupivacaine , Granisetron , Sensory block , Motor block , Anesthesia , Spinal , Outpatients , Cystoscopy