Effect of Magnesium Sulfate on Hemodynamic Changes During Sternotomy and Laryngoscopy inCoronary Artery Bypass Graft Surgery: A Randomized Clinical Trial
Publish place: Academic Journal of Surgery، Vol: 3، Issue: 1
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_AJS-3-1_002
تاریخ نمایه سازی: 17 مرداد 1396
Abstract:
Background: This study was designed to evaluate the effectiveness of low and high dose magnesium sulfate inreducing pressure responses to laryngoscopy and sternotomy.Methods: A total of 90 patients were assigned into three groups. The patients in Group L received a 20 mg/kgbolus dose of magnesium sulfate 3 minutes before intubation followed by an infusion of magnesium sulfate (10mg/kg/h) in contrast to 40 mg/kg of magnesium sulfate followed by an infusion of 20 mg/kg/h magnesiumsulfate administered to Group H. Patients in Group P received saline as placebo. Heart rate and mean arterialpressure (MAP) recorded at the baseline were noted down again before intubation and 30 seconds, 2 and4 minutes after intubation and 1 minute before, and 30 seconds, 2 and 4 minutes after sternotomy.Results: MAP in Groups L and H compared to Group P was significantly lower, after intubation (P = 0.0040).The difference between MAP in Groups L and H was only statistically significant 30 seconds after intubation.MAP 30 seconds and 2 minutes after sternotomy was statistically different between Groups L and H comparedto Group P. The difference between Groups H and P was only statistically significant before sternotomy and4 minutes after sternotomy (P = 0.0001).Conclusions: A low dose magnesium sulfate attenuates the hemodynamic response to laryngoscopy andsternotomy in coronary artery bypass graft surgery.© 2014 Tehran University of Medical Sciences. All rights reserved.Citation: Marashi SM, Azimaraghi O, Hejazian-Yazdi A, Movafegh A. Movafegh A. Effect of Magnesium Sulfate on Hemodynamic Changes During Sternotomy and Laryngoscopy in Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial, Acad J Surg,, 2016; 3(1-2): 19-23.
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Authors
Seyed Mojtaba Marashi
Associate Profeesor, Department of Anesthesiology, Dr. Ali Shariati Hospital. Tehran University of Medical Sciences, Tehran, Iran
Omid Azimaraghi
Associate Profeesor, Department of Anesthesiology, Dr. Ali Shariati Hospital. Tehran University of Medical Sciences, Tehran, Iran
Alireza Saliminia
Anesthesiologist, Research Development Center, Dr. Ali Shariati Hospital, Tehran University of medical Sciences, Tehran, Iran
Reza Atef-Yekta
Professor, Department of Anesthesiology, Dr. Ali Shariati Hospital. Tehran University of Medical Sciences, Tehran, Iran