Analysis and presentation of the results of bone marrow transplantation in patients with non-hodgkin s lymphoma and hodgkin s lymphoma : survival analysis using an accelerated failure-time regression model

Lymphoma is a type of cancer that starts in the white blood cells (infection-fighting cells) and develop in the lymphatic system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma(NHL). In Iran, The incidence of malignant lymphoma is higher than in western countries. Bone marrow transplantation (BMT) or stem cell transplantation (SCT) can restore damaged bone marrow following high-dose chemotherapy or radiation therapy. The aim of this study is analysis and presentation of the results of bone marrow transplantation in patients with lymphoma, using an accelerated failure-time (AFT) regression model. In the present study from 2007 to 2016, 205 cases of malignant lymphoma various types of Hodgkin and non-Hodgkin lymphomas who had received bone marrow transplantation, collected from Taleghani Hospital. In order to identify factors affecting their survival, the Weibull AFT model was fitted to the data. All calculations were carried out using STATA software version 11 and SPSS version 21.0, at the 0.05 level of significance. Out of 205 patients, 53 (25.9%) had NHL and 152 (74.1%) HL; the mean (± standard deviation) survival time was 79.60±3.64 months. The mean age at diagnosis was 32.66 ± 10.8 years (range = 16~65 years). Among all the patients, 190(92.7%) patients received autologous bone marrow transplantation. Based on the Weibull AFT model, age (HR=1.05, p=0.006) had significant effects on patient survival. According to the results of multivariate analysis, Our study showed that age of the patients is an effective factor on lymphoma patient s survival. Therefore, to extend the survival of these patients, this factor should be counted on

Keywords:

Blood Cancer , Cell and Cancer , Stem Cells and Cancer , Cancer Treatment and Management , Targeted Cancer Therapy