Cytotoxicity effects of silver nanoparticles on cancer cells

Today, cancer is one of the most common causes of mortality in the world. Cancer is a group of diseases cause abnormal cell growth. Cancer has many kinds that, unfortunately, do not found definitive treatment for any of them. Recently, the use of nanoparticles is one of the most common treatment methods of cancer. Some silver nanoparticles have been considered for their high toxicity and anti-cancer and anti-angiogenesis effects, and are considered as potent anticancer agents. MTT test has been done on human colon cancer (HCT-116), breast (MCF-7), liver (Hep-G2) and intestinal (Caco-2) cancer cells, which shows that the nanoparticle has anticancer effects. Ag nanoparticles play a role in damaging DNA and triggering a planned cell death (apoptosis). The silver nanoparticles coated with curcmin cause planned cell death in ovarian cancer cells (A278) and inhibit proliferation of these cells.In this method was used to stabilize Ag nanoparticles using curcumin as reducing agent. This nanoparticle in the gelatin bed causes high apoptosis in the uterine cancer cell line that causes cancer cells to die. The gelatin bed releases nanoparticles of silver. The silver nanoparticles increase the expression of the MT-2A and ho-1 genes causing the planned death of Hela cells. By increasing the density of nanoparticles synthesized from palm kernel extract breast cancer cellular (MCF-7) stability decreases as much as possible. That is, the inhibitory effect of silver nanoparticles depends on its density, as the density increases, cell cytotoxicty increases. This nanoparticle inhibits the G1 and G0 phases and reduces the synthesis of DNA and induces apoptosis in intestinal cancer cells. Silver nanoparticle also induces cell death in the A549 lung cells via the mt mediated intrinsic apoptotic program. In general, nanoparticles of silver have toxic effects for cancer cells and it is known for its antimicrobial effects, while they are safe for normal human cells.

Keywords:

Cancer Prevention , Cell and Cancer , Multidisciplinary Cancer Research , Cancer Treatment and Management , Drugs and Cancer