Association of ANRIL (rs1333045) Gene Polymorphism with the Risk of Acute Myeloid Leukemia

Background and Aim: Dysregulation of cell cycle genes can lead todifferent kind of cancers. It has become apparent that lncRNAs are animportant regulator of the gene expression. Promotor polymorphisms are one of the main reasons for gene expression dysregulation. ANRILwhich also known as CDKN2B-AS is a lncRNA that located within thep15/CDKN2B-P16/CDKN2A-p14/ARF gene cluster. Single nucleotidepolymorphisms of this gene are associated with many diseases,particularly cancers. The aim of this study was to evaluate the associationof ANRIL polymorphism with acute myeloid leukemia in Iranian patientsMethods: In the present study, AML patient and age- and sex-matchedcontrol were included.Results: The results showed no significant association of alleles andgenotype frequency of ANRIL (rs1333045) polymorphism between AMLpatients and control subjects.Conclusion: We didn’t find a significant association between ANRIL(rs1333045) polymorphism and the risk of acute myeloid leukemia.

Keywords:

Association , Polymorphism , ANRIL , Acute myeloid leukemia