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The Hormonal Effect of The Artificial Sweetener (Acesulfame Potassium) on Adult Male Rats

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Year: 2019
COI code: RROYAN20_340
Paper Language: English

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Authors The Hormonal Effect of The Artificial Sweetener (Acesulfame Potassium) on Adult Male Rats

R Zereshki - Department of Biology, Payam-e-Noor University, Isfahan, Iran.
  A Noori - Department of Biology, Falavarjan Branch, Islamic Azad Univer-sity, Isfahan, Iran.
AA Pilevarian - Department of Biology, Payam-e-Noor University, Isfahan, Iran.

Abstract:

Background: Acesulfame potassium is a low-calorie artificial sweetener. It is important to know its possible health effects because of high consumption of acesulfame potassium. There-fore, this study aimed to investigate effect of the intraperitoneal administration of acesulfame potassium in pregnancy and after lactation on adult male offspring sexual and gonadotropin hor-mones.Materials and Methods:In this study, acesulfame potassium with four different doses, 50 mg, 100 mg, 200 mg and 400 mg/ kg body weight was injected intraperitoneally to pregnant rats (wistar) and then to their adult offspring after lactation until 60th. Blood samples were also collected after puberty and the levels of FSH, LH and testosterone were measured by us-ing Elisa method. Also, mother s rats and their offspring were weighted during study. ANOVA was used to compare data be-tween groups.Results: The mean weight in both treatment groups with con-centrations of 50 and 200 mg / kg was significantly higher than that in controls and the other groups. There was no statistically significant difference in LH levels between different groups. Administration of acesulfame potassium significantly reduced FSH levels in neonates who received two different doses of 50 mg and 100 mg/kg BW (P<0.01). Testosterone level was sig-nificantly (P<0.001) increased in 50 mg/kg 200 mg/kg and 400 mg/kg as compared with controls.Conclusion: It seems that the use of acesulfame potassium as an artificial sweetener in food products and its use by pregnant mothers and infants probably have hormonal effects, although there is no evidence that this alteration causes spermatogenesis changes.

Keywords:

Acesulfame Potassium, Pregnancy, Testosterone, Male Rat

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COI code: RROYAN20_340

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Zereshki, R; A Noori & AA Pilevarian, 2019, The Hormonal Effect of The Artificial Sweetener (Acesulfame Potassium) on Adult Male Rats, 20th congress on reproductive biomedicine and 15th congress on stem cell biology & technology, تهران, پژوهشگاه رويان, https://www.civilica.com/Paper-RROYAN20-RROYAN20_340.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Zereshki, R; A Noori & AA Pilevarian, 2019)
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