Renoprotective potential of exogen erythropoietin on experimental ruptured abdominal aortic aneurysm model: An animal study
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 23، Issue: 2
Publish Year: 1398
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-23-2_017
تاریخ نمایه سازی: 27 مرداد 1399
Abstract:
Objective(s): The aim of this study is to investigate the renoprotective effect of erythropoietin (EPO) on hypovolemic shock and ischemia/reperfusion (IR) injury on kidneys as end-organs in an experimentally-created ruptured abdominal aortic aneurysm (rAAA) model.Materials and Methods: Thirty anesthetized Sprague-Dawley male rats were randomized to sham ((Sh n:6) (Sh+EPO n:6)) or shock and I/R groups ((S/IR n:9) (S/IR+EPO n:9)). Additional surgical procedure except aortic exploration was not performed on Sh and Sh+EPO groups. 60 min of shock, 60 min of ischemia, and 120 min of reperfusion were applied on S/IR and S/IR+EPO groups. In the S/IR and S/IR+EPO groups, hemorrhagic shock, lower torso ischemia, and reperfusion were created. At the end of the shock period, saline solutions were separately and equally administered to Sh and S/IR groups, whereas 2000 U/kg EPO was intraperitoneally administered to Sh+EPO and S/IR+EPO groups. At the end of the experimental study, some biochemical and histological parameters were studied in serum and kidney tissues.Results: Biochemical parameters were all significantly increased in the S/IR group compared with the Sh group. These parameters were not statistically significantly different between S/IR+EPO and Sh+EPO groups. In histopathologic examination, EPO prevented high-grade injury.Conclusion: Our data indicate that EPO may have a renoprotective effect and reduce the systemic inflammatory response that resulted from shock and I/R in an experimental model of rAAA.
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Authors
Gokalp Altun
Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, ۶۱۰۸۰ Trabzon, Turkey
Yavuz Cakiroglu
Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, ۶۱۰۸۰ Trabzon, Turkey
Zerrin Pulathan
Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, ۶۱۰۸۰ Trabzon, Turkey
Esin Yulug
Department of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, ۶۱۰۸۰ Trabzon, Turkey
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