Copper-catalyzed synthesis of novel 1,2,3-triazole-linked indoles

A new series of indole-based 1,2,3-triazole derivatives are synthesized by the reaction of 2-aryl-1-(prop-2-ynyl)-1H-indole-3-carbaldehydes with aromatic azides via copper-catalyzedazide-alkyne cycloaddition reactions in the presence of Cu(OAc)2 as a catalyst in ethanole.These reaction procedures have the advantages of good-to-high yields, short reaction times,mild experimental conditions, and operational simplicity.

Keywords:

1 , 2 , 3-Triazole , Click reaction , Indole , Aromatic azide