Effects of Cumin Extract on Serum Lipid Profile and Total Antioxidant Capacity in Rats Receiving High-Fat Diet
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_ZUMS-25-110_002
تاریخ نمایه سازی: 11 اردیبهشت 1400
Abstract:
Background and Objective: Obesity is a serious global health problem. In this study the effects of cumin extract in rats receiving high fat diets were investigated and compared with metformin.
Materials and Methods: Eighty rats were divided into two sets of forty and each set was divided into four groups: the first group was a control group, the second group received a high fat diet, the third group received a high fat diet with metformin and forth group received a high fat diet with an extract of cumin. After treatment Malondialdehyde (MDA), catalase and antioxidant capacity (FRAP) were measured.
Results: In the first set, the weight of the second group increased in comparison to the group receiving a normal diet. Weight in rats receiving metformin in combination with cumin extract decreased compared to the second group. MDA in rats belonging to the second group showed a greater increase compared to the control group, however FRAP was decreased.
Results gathered from the second set are as follows: MDA increased in rats belonging to the second group more than the control group but, FRAP and catalase declined. MDA and catalase increased in the metformin group compared to the second group. PON۱ activity, catalase and FRAP in cumin receiving rats increased compared to the second group and MDA declined.
Conclusion: The results of the present study suggest that cumin extract has better protective effects against oxidative stress in high fat diet and obesity in comparison to metformin in rats.
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Authors
اکرم یعقوبی
Dept. of Biochemistry, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
کیهان قطره سامانی
Clinical Biochemistry Research Centre, Shahrekord University of Medical Sciences, Shahrekord, Iran
سیداسدالله امینی
Cellular and Molecular Research Centre, Shahrekord University of Medical Sciences, Shahrekord, Iran
مصطفی غلامی
Clinical Biochemistry Research Centre, Shahrekord University of Medical Sciences, Shahrekord, Iran
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