Incidence of Multidrug-Resistant, Extensively Drug-Resistant, and Pandrug-Resistant Pseudomonas aeruginosa Strains Isolated from Clinical Specimens
Publish place: Infection Epidemiology and Microbiology، Vol: 6، Issue: 3
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IEM-6-3_006
تاریخ نمایه سازی: 28 تیر 1400
Abstract:
Aims: Recently, overuse and misuse of antibiotics have led to the development of multidrug-resistant bacteria and infectious diseases caused by these organisms, increasing morbidity and mortality rate in patients. Pseudomonas aeruginosa as a common Gram-negative pathogen is predominantly responsible for hospital-acquired infections. In this study, the prevalence of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pandrug-resistant (PDR) P. aeruginosa strains isolated from clinical specimens of patients admitted to a teaching hospital in Gorgan, Iran, was determined.
Materials & Methods: Clinical samples of blood, urine, burn wound, eye, and secretions (pleural fluid, tracheal or bronchial aspirates and sputum) were collected from all hospitalized patients during a three-month period from April to June ۲۰۱۹. Using conventional biochemical methods, P. aeruginosa strains were identified, and the antibiotic resistance pattern was determined by Kirby-Bauer disc diffusion method.
Findings: A total of ۴۰ (۲۵.۴%) P. aeruginosa strains were isolated from ۳۷۷ clinical specimens. Most of the P. aeruginosa strains were isolated from wound (۳۵%) and urine (۳۰%) samples. Most of the P. aeruginosa positive samples were recovered from intensive care unit (۳۲.۵%) and burn ward (۳۰%). The highest susceptibility was shown to fosfomycin (۱۰۰%), and the lowest susceptibility was observed to ceftazidime (۸۷.۵%), followed by aztreonam (۶۰%). Based on the results, ۵۲.۵ and ۲۰% of the isolates were MDR and XDR, respectively. All of the MDR isolates exhibited susceptibility to colistin. No PDR phenotype was observed.
Conclusion: Continuous monitoring of drug resistant strains among clinical isolates of P. aeruginosa must be done to adopt effective strategies to decrease the threat of antimicrobial resistance.
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Authors
Fatemeh poudineh
Department of Microbiology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Ania Ahani Azari
Department of Microbiology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
Leila Fozouni
Department of Microbiology, Gorgan Branch, Islamic Azad University, Gorgan, Iran
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