Epithelial-mesenchymal transition in breast cancer
Publish place: Personalized Medicine Journal، Vol: 6، Issue: 21
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_PMJ-6-21_004
تاریخ نمایه سازی: 11 مرداد 1400
Abstract:
One of the key molecular mechanisms contributing to the metastatic progression is epithelial to mesenchymal transition (EMT), which drives invasion and migration of various cancer including breast cancer.During tumorigenesis, changes in EMT regulatory pathways lead to a loss of cellular adhesions, changes in the polarization of the cell and cytoskeleton, detachment, migration, intra-vasation, and survival in the vascular system; extravasation, and finally, metastasis.EMT is largely mediated by a core set of EMT-activating transcription factors. The master regulators of the EMT include many pathways, however the primary mediators of the EMT include signaling through TGF-, Notch and Wnt. The role of EMT in breast cancer has been demonstrated via numerous in vitro studies in normal and malignant mammary epithelial cells and via in vivo studies using mouse models of breast cancers. Studying the regulatory pathways of the EMT process can be used as a tool for cancer monitoring ,treatment and possible direct targets for new-combination anticancer personalized medicine.
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Authors
Mohammad Ali Saremi
Personalized Medicine Research Center of AmitisGen, Tehran, Iran
Nafise Poorhasan
Department of Cellular and Molecular biology , Faculty of Biological Sciences, North Tehran Branch, Islamic Azad University, Tehran, Iran