Angiotensin (۱-۷) levels and disease severity in hospitalized COVID-۱۹ patients with and without cardiovascular diseases

Background and Aim : Angiotensin (۱-۷) (Ang (۱-۷)) obtained from the function of angiotensin-converting enzyme ۲ (AEC۲) improve heart and lung function. Blockade of ACE۲ by severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) in coronavirus disease ۲۰۱۹ (COVID-۱۹) decreases Ang (۱-۷). In this study, we investigated Ang (۱-۷) levels and disease severity in hospitalized COVID-۱۹ patients with and without cardiovascular diseasesMethods : To do so, the Ang (۱-۷) levels of hospitalized COVID-۱۹ patients with (۱۳۶) and without (۱۲۷) cardiovascular disease in Masih-Daneshvari Hospital, Tehran, Iran were measured by ELIZA kit. , the patients’ clinical symptoms, including intensive care unit (ICU) admission, the use of mechanical ventilation, oxygen need, fever, and gastrointestinal disorders were drawing out from the patient's medical record.Results : Results of our investigation showed a significant inverse relationship between the levels of Ang ۱-۷ and the severity of the disease (P value = ۰.۰۰۰). But there wasn’t significant difference between the levels of Ang ۱-۷ in hospitalized COVID-۱۹ patients with and without cardiovascular diseases.Conclusion : Ang (۱-۷) reduced the severity of COVID-۱۹ disease, both in patients with and without cardiovascular

Keywords:

Angiotensin (۱-۷) , angiotensin-converting enzyme ۲ , severe acute respiratory syndrome coronavirus ۲