Protosappanin A protects against atherosclerosis via anti- hyperlipidemia, anti-inflammation and NF-κB signaling pathway in hyperlipidemic rabbits
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 21، Issue: 1
Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
View: 167
This Paper With 6 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-21-1_006
تاریخ نمایه سازی: 27 مهر 1400
Abstract:
Objective(s): Protosappanin A (PrA) is an effective and major ingredient of Caesalpinia sappan L. The current study was aimed to explore the effect of PrA on atherosclerosis (AS). Materials and Methods: Firstly, the experimental model of AS was established in rabbits by two-month feeding of high fat diet. Then, the rabbits were randomly divided into five groups and treated with continuous high lipid diet (model control), high lipid diet containing rosuvastatin (positive control), ۵ mg/kg PrA (low dose) or ۲۵ mg/kg PrA (high dose). Results: Our results showed that PrA markedly alleviated AS as indicated by hematoxylin/eosin (HE) staining. PrA also reduced hyperlipidemia (as demonstrated by the serum levels of total blood cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL)) in a time and dose-dependent manner, and decreased inflammation (as indicated by the serum levels of matrix metalloproteinase-۹ [MMP-۹], interleukin-۶ [IL-۶] and tumor necrosis factor-α [TNF-α]). Moreover, PrA significantly inactivated nuclear factor kappa B (NF-κB) signaling as indicated by nuclear NF-κB p۶۵ protein expression, as well as the mRNA expression and serum levels of downstream genes, interferon-γ (IFN-γ) and interferon-gamma-inducible protein ۱۰ (IP۱۰). Conclusion: This study proved that PrA might protect against atherosclerosis via anti-hyperlipidemia, anti-inflammation and NF-κB signaling pathways in hyperlipidemic rabbits.
Keywords:
Authors
Ying Huang
Department of Cardiology, Shang Hai PuDong New Area People’s hospital, Shanghai, China
Yuan Qi
Department of Cardiology, Shanghai East Hospital, New Area of Pu Dong, Shanghai, China
JianQing Du
Department of Cardiology, Shang Hai PuDong New Area People’s hospital, Shanghai, China
DaiFu Zhang
Department of Cardiology, Shang Hai PuDong New Area People’s hospital, Shanghai, China
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :