Swimming training alleviated insulin resistance through Wnt۳a/β-catenin signaling in type ۲ diabetic rats

Publish Year: 1396
نوع سند: مقاله ژورنالی
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JR_IJBMS-20-11_007

تاریخ نمایه سازی: 28 مهر 1400

Abstract:

Objective(s): Increasing evidence suggests that regular physical exercise improves type ۲ diabetes mellitus (T۲DM). However, the potential beneficial effects of swimming on insulin resistance and lipid disorder in T۲DM, and its underlying mechanisms remain unclear. Materials and Methods: Rats were fed with high fat diet and given a low dosage of Streptozotocin (STZ) to induce T۲DM model, and subsequently treated with or without swimming exercise. An ۸-week swimming program (۳۰, ۶۰ or ۱۲۰ min per day, ۵ days per week) decreased body weight, fasting blood glucose and fasting insulin. Results: Swimming ameliorated lipid disorder, improved muscular atrophy and revealed a reduced glycogen deposit in skeletal muscles of diabetic rats. Furthermore, swimming also inhibited the activation of Wnt۳a/β-catenin signaling pathway, decreased Wnt۳a mRNA and protein level, upregulated GSK۳β phosphorylation activity and reduced the expression of β-catenin phosphorylation in diabetic rats. Conclusion: The trend of the result suggests that swimming exercise proved to be a potent ameliorator of insulin resistancein T۲DM through the modulation of Wnt۳a/β-catenin pathway and therefore, could present a promising therapeutic measure towards the treatment of diabetes and its relatives.

Authors

Qiang Yang

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Wen-wen Wang

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Pu Ma

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Zhong-xuan Ma

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Meng Hao

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Temitope I Adelusi

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Lei Du

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Xiao-Xing Yin

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

Qian Lu

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou ۲۲۱۰۰۲, Jiangsu, China

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