The effect of spinally administered WIN ۵۵,۲۱۲-۲, a cannabinoid agonist, on thermal pain sensitivity in diabetic rats

Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IJBMS-19-4_008

تاریخ نمایه سازی: 30 مهر 1400

Abstract:

Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN ۵۵,۲۱۲-۲, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Diabetes was induced in rats using a single dose of streptozotocin (۴۵ mg/kg IP). Results: Intrathecal (IT) administration of WIN۵۵, ۲۱۲-۲ (۱, ۱۰, ۱۰۰ µg/۱۰ µl, IT), produced antinociceptive effects in the hot plate test and also improved nerve conduction velocity (۱۰۰ µg/۱۰ µl, IT) and sciatic nerve histology. Conclusion: These data show that cannabinoids have potent antinociceptive effects through direct actions in the spinal dorsal horn of nociceptive pathway. This suggests that intrathecally administered cannabinoids may offer hopeful strategies for the treatment of diabetic neuropathic pain.

Authors

Samane Jahanabadi

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Mohamad Reza Hadian

Department of Physical Therapy, Faculty of Rehabilitation Sciences, Tehran University of Medical Sciences, Tehran, Iran

Javad Shamsaee

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Seyed Mohammad Tavangar

Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Alireza Abdollahi

Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Ahmadreza Dehpour

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Shahram Ejtemaei Mehr

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

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