Design, Synthesis and Antimicrobial Activity Evaluation of New Bisimidyl Sulfonamido Ketone Comprising Drug component
Publish place: Chemical Methodologies، Vol: 5، Issue: 6
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_CHM-5-6_003
تاریخ نمایه سازی: 1 آبان 1400
Abstract:
This work involved design and synthesis of four new compounds which their molecules contain three biologically active segments, including β-lactam containing drug, cyclic imide and sulfonamido group. Synthesis of the compounds was performed by several steps. In the first step, compound (۱) bis[N-phenyl phthalamic acid] ketone was synthesized via reaction of aniline with benzophenone ۳,۳’,۴,۴’-tetra carboxylic dianhydride. In the second step, compound (۱) was dehydrated by fusion to give the corresponding bis phthalimide (۲) which in turn was introduced in reaction with chloro sulfonic acid. The third step involved producing compound (۳), the corresponding bis phthalimidyl benzene sulfonyl chloride. Compound (۳) is the important key compound from which the target compounds (۴-۷) were prepared through its reaction with different β-lactam containing drugs. Antibacterial and antifungal activities of compounds (۴-۷) were screened and the results indicated that they have high biological activity.
Keywords:
β -lactam containing drugs , bis [N-phenyl phthalamic acid] ketone , cyclic imide , Sulfonamido group
Authors
Zaynab Fadel
Department of Chemistry, College of Science, University of Baghdad, Jadiriya, Baghdad, Iraq
Ahlam Marouf Al-Azzawi
Department of Chemistry, College of Science, University of Baghdad, Jadiriya, Baghdad, Iraq
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