Effect of Aqueous-Ethanolic Extract from Rosa damascena on Guinea Pig Isolated Heart
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 14، Issue: 2
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-14-2_003
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) In the present study, the effects of aqueous-ethanolic extract from Rosa damascena on heart rate and contractility were examined. Materials and Methods Isolated guinea-pig hearts were perfused through aorta in a Langendorff mode. Heart rate (HR) and contractility were determined in the presence of four concentrations of the extract (۰.۱, ۰.۲, ۰.۴ and ۱.۰ mg %) and isoprenaline (۱, ۱۰, ۱۰۰ nM and ۱ μM) in comparison with baseline values in the presence and absence of propranolol (n= ۱۰ for each group). Results Both isoprenaline and the extract caused increase in heart rate and contractility (P< ۰.۰۵ to P< ۰.۰۰۱). The percent increased in HR due to the final concentration of isoprenaline in the absence of propranolol was significantly greater than that of the extract (P< ۰.۰۱). Propranolol caused significant reduction in both HR and contractility (P< ۰.۰۵ for both) but this effect was significantly reversed by isoprenaline and the extract (P< ۰.۰۵ to P< ۰.۰۰۱). The percent increased in heart contractility due to the final concentration of the extract in the absence and presence of propranolol was significantly greater than that of isoprenaline (P< ۰.۰۵ for both cases). There was significant correlation between both HR and heart contractility with concentration of isoprenaline and the extract (P< ۰.۰۵ to P< ۰.۰۰۱). Conclusion In conclusion this study showed a relatively potent inotropic and chornotropic effect for Rosa damascena on isolated guinea-pig heart.
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Authors
Mohammad Hossein Boskabady
Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Alaleh Vatanprast
Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Hydar Parsee
Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Mahbobeh Ghasemzadeh
Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
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