Preparation, Characterization and Evaluation of Sun Protective and Moisturizing Effects of Nanoliposomes Containing Safranal
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 14، Issue: 6
Publish Year: 1390
نوع سند: مقاله ژورنالی
زبان: English
View: 144
This Paper With 13 Page And PDF Format Ready To Download
- Certificate
- من نویسنده این مقاله هستم
استخراج به نرم افزارهای پژوهشی:
شناسه ملی سند علمی:
JR_IJBMS-14-6_005
تاریخ نمایه سازی: 3 آبان 1400
Abstract:
Objective(s) The objective of this study was to prepare, characterize and evaluate the nanoliposomes containing safranal as a natural sunscreen and moisturizer factor. Materials and Methods The experimental formulations included homosalate reference, nanoliposomes containing ۰.۲۵, ۰.۵, ۱, ۲, ۴ and ۸% safranal and empty liposomes. The liposomes were prepared using fusion method and homogenization. Homosalate reference was prepared according to FDA standard. Sun protection factors (SPF) of the formulations were determined by two in vitro methods; diluted solution transmittance method and transpore tape method. Studies of in vitro penetration of the formulations across mouse skin were carried out with diffusion cells. The percentage of safranal penetrated and retained in the skin was determined for the formulations up to ۲۴ hr. The amount of the moisture contents of the skin before application and after ۳۰- minute, ۱, ۳ and ۵ hr post-application of the formulations were measured in human volunteers using Corneometer. Results The results indicated that, the SPF of liposomes containing ۸% safranal (Lip-Safranal ۸%) was significantly higher than ۸% homosalate reference. The proportion of Lip-Safranal ۱% that penetrated the skin was low. There was no significant difference between the skin moisture contents after application of Lip-Safranal ۱ and ۴% and empty liposomes during the ۷ hr post-application period. Conclusion These results showed that in equal concentrations, Lip-Safranal could act as a better antisolar agent compared to homosalate and have no moisturizing effect in ۱ and ۴% concentrations.
Keywords:
Authors
Shiva Golmohammadzadeh
Nanotechnology Research Centre, Mashhad, University of Medical Sciences, Mashhad, Iran
Fatemeh Imani
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Hossein Hosseinzadeh
Pharmaceutical Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Reza Jaafari
Biotechnology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
مراجع و منابع این Paper:
لیست زیر مراجع و منابع استفاده شده در این Paper را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود Paper لینک شده اند :