Safranal-loaded solid lipid nanoparticles: evaluation of sunscreen and moisturizing potential for topical applications
Publish place: Iranian Journal of Basic Medical Sciences، Vol: 18، Issue: 1
Publish Year: 1394
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-18-1_009
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Objective(s): In the current study, sunscreen and moisturizing properties of solid lipid nanoparticle (SLN)-safranal formulations were evaluated. Materials and Methods:Series of SLN were prepared using glyceryl monostearate, Tween ۸۰ and different amounts of safranal by high shear homogenization, and ultrasound and high-pressure homogenization (HPH) methods. SLN formulations were characterized for size, zeta potential, morphology, thermal properties, and encapsulation efficacy. The Sun Protection Factor (SPF) of the products was determined in vitro using transpore tape. The moisturizing activity of the products was also evaluated by corneometer. Results: The SPF of SLN-safranal formulations was increased when the amount of safranal increased. Mean particle size for all formulas was approximately ۱۰۶ nm by probe sonication and ۲۳۳ nm using HPH method. The encapsulation efficiency of safranal was around ۷۰% for all SLN-safranal formulations. Conclusion: The results conclude that SLN-safranal formulations were found to be effective for topical delivery of safranal and succeeded in providing appropriate sunscreen properties.
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Authors
Bahman Khameneh
Department of Food and Drug Control, Mashhad University of Medical Sciences, Mashhad, Iran
Vahid Halimi
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Mahmoud Reza Jaafari
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Shiva Golmohammadzadeh
Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
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