Pathogenesis of Epilepsy: Challenges in Animal Models
Publish Year: 1392
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJBMS-16-11_001
تاریخ نمایه سازی: 4 آبان 1400
Abstract:
Epilepsy is one of the most common chronic disorders affecting individuals of all ages. A greater understanding of pathogenesis in epilepsy will likely provide the basis fundamental for development of new antiepileptic therapies that aim to prevent the epileptogenesis process or modify the progression of epilepsy in addition to treatment of epilepsy symptomatically. Therefore, several investigations have embarked on advancing knowledge of the mechanism underlying epileptogenesis, understanding in mechanism of pharmacoresistance and discovering antiepileptogenic or disease-modifying therapy. Animal models play a crucial and significant role in providing additional insight into mechanism of epileptogenesis. With the help of these models, epileptogenesis process has been demonstrated to be involved in various molecular and biological pathways or processes. Hence, this article will discuss the known and postulated mechanisms of epileptogenesis and challenges in using the animal models.
Keywords:
Animal models Epileptogenesis Pathogenesis of epilepsy Temporal lobe epilepsy
Authors
Yow Hui Yin
Faculty of Pharmacy, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Nurulumi Ahmad
Faculty of Pharmacy, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Mohd Makmor-Bakry
Faculty of Pharmacy, University Kebangsaan Malaysia, Kuala Lumpur, Malaysia
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