Determination of the Quantity of Losartan Active Ingredient in the Medication Formulations via Turbidimetric-Flow Injection Technique

This study describes a rapid and sensitive method for determination of Losartan potassium (LOS-K) in pure and medication forms. The method is depended upon the reaction of LOS-K with Silicotungestic acid in salt medium for the formation of a white precipitate. The new precipitate was monitored and measured using homemade Ayah ۶SXI-T-۲D Solar cell analyzer in combination with a continuous flow injection technique. Reagent concentration, acid medium, flow rate, sample volume, purge time, and delay coil reaction are all chemical and physical characteristics that have been investigated and optimized. The linear dynamic range of LOS-K was ۰.۰۵-۲ mMol/L with linearity percentage (r۲%) ۹۹.۵۶ %. Limit of detection (LOD) was ۳.۶۲ µg/sample and LOQ=۱۸.۲۸ µg/sample. A comparison between developed method and classical methods (UV-Spectrophotometry at λmax= ۲۳۲ nm) was made. The proposed method was successfully applied for determination of LOS-K in the pharmaceutical samples and can be used as an alternative method.

Keywords:

Losartan potassium , Silicotungestic acid , Turbidimetric method , Flow injection analysis