Fetal dosimetry for ۱۸F-FDG PET Imaging during pregnancy: a comparative Monte Carlo study
Publish place: Iranian Journal of Medical Physics، Vol: 18، Issue: 6
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJMP-18-6_012
تاریخ نمایه سازی: 20 آذر 1400
Abstract:
Introduction: Current reported values of fetal doses from ۱۸F Fluorodeoxyglucose (FDG) in pregnant women imaged with PET scan showed a significant variation. This study aimed to evaluate fetal radiation doses using the last generation of computational pregnant phantoms and also to shed light on one of the uncertainty components of the fetal dose. Material and Methods: In this respect, we used a boundary representation (BREP) series of computational pregnant phantoms to evaluate radiation doses to the fetus. We also reviewed available data on fetal time-integrated activities and evaluated the confidence and prediction (۹۵%) intervals for the existing data. By doing this, the uncertainty of fetal Biokinetic data was taken into account in fetal dose calculations. Results: The fetal doses of ۲.۳۰E-۰۲, ۱.۵۳E-۰۲, and ۱.۰۲E-۰۲ mGy/MBq at ۳, ۶ and ۹ months of gestation were estimated. The results also showed the contributions of source organs to the fetal doses. The maternal “urinary bladder contents” and “other organs and tissues” are the main source regions contributing to fetal dose. We also indicated that the Biokinetic variation caused a large uncertainty on fetal dose (with a prediction interval from ۱.۷۳E-۰۲ to ۳.۹۳E-۰۲ mGy/MBq) at the first trimester of pregnancy, while it is much lower at second and third trimesters. Furthermore, it is indicated that variations on fetal dose outside the determined intervals may be related to the geometrical differences of used computational phantoms. Conclusion: Since the fetal dose is much higher and the radiation exposure is more deterministic at the first trimester of pregnancy, attempting to evaluate the fetal dose is relevant at this stage accurately.
Keywords:
۱۸F , FDG PET Imaging Radiation Dosimetry Pregnancy
Authors
Nadia Zarghi
Physics Department, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Seyed Hashem Miri-Hakimabad
Physics Department, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Elie Hoseinian-Azghadi
Physics Department, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.
Najmeh Mohammadi
Physics Department, Faculty of Science, Sahand University of Technology, Tabriz, Iran
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