Effect of Germinated Black Rice Krisna Extract on Fasting Blood Glucose and Body Weight in Diabetes Mellitus Rats
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJNS-6-4_006
تاریخ نمایه سازی: 15 دی 1400
Abstract:
Background: Diabetes mellitus (DM) is a non-communicable disease that is generally associated with fasting blood glucose (FBG) level of >۱۲۶ mg/dL and weight loss. Germinated black rice krisna (GBRK) extract contains phytochemicals with antioxidant and anti-diabetic properties. The purpose of this study was to assess the impact of GBRK extract on FBG level and body weight (BW) in rat model of DM.Methods: In an in vivo pre- and post-test study ۳۶ male Wistar rats with BW design, of ۱۵۰-۲۰۰ g were enrolled and divided into ۶ groups, including control (C), negative control (NC), GBRK ۵۳۵ mg/kg BW (P۱), GBRK ۱۰۷۰ mg/kg. BW (P۲), and GBRK ۲۱۴۰ mg/kg BW (P۳). Diabetes was induced using streptozotocin (STZ) and nicotinamide (NA) and the intervention period was ۱۴ days. Measurement of FBG level was by quantitative enzymatic colorimetric test of Glucose Oxidase Phenol ۴-Aminoantipyrine (GOD-PAP) and body weight was determined by a digital scale.Results: The administration of GBRK extract in P۱, P۲, and P۳ groups could significantly reduce the FBG (p <۰.۰۱). GBRK in P۱, P۲, and P۳ groups could also significantly improve the body weight to normal state too (p <۰.۰۱).Conclusion: GBRK extract at doses of ۵۳۵, ۱۰۷۰, and ۲۱۴۰ mg/kg BW for ۱۴ days was demonstrated to improve metabolic disorders in diabetes by reducing FBG level and improving the BW to the normal state.
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Authors
Sudana Pasaribu
Departement of Nutrition, Postgraduate, Universitas Sebelas Maret, Surakarta, Indonesia
Budiyanti Wiboworini
Department of Nutrition, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Lilik Kartikasari
Departement of Animal Science, Faculty of Agriculture, Universitas Sebelas Maret, Surakarta, Indonesia