Numerical Investigation of Bile Secretion and Pressure Rise in Obstructed Human Common Bile Duct
Publish place: Journal of Applied Fluid Mechanics، Vol: 14، Issue: 1
Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JAFM-14-1_021
تاریخ نمایه سازی: 15 دی 1400
Abstract:
A fully obstructed Common Bile Duct (CBD) could lead to severe implications such as jaundice, cholangitis, and pancreatitis. A ۲-D CFD model with the employment of Fluid-structure Interaction (FSI) formulations is established to investigate the interactions of bile with its surroundings. Ascertaining bile secretion against a total CBD obstruction is a major interest of this study. Therefore, a function is assigned to bile secretion pattern such that the resulting intraluminal pressure complies with clinical data. To cover the variation in the parameters representing the mechanical properties of the biliary system as well as bile secretion, specific piecewise ranges are given for each of them and consequently, numerous cases are simulated. Models which after simulation lead to pressure rises in the interval of ۷۰۰ Pa to ۱۳۰۰ Pa are picked. This interval could roughly include the actual pressure rise of a vast majority of patients. It is determined that among numerous cases, higher distention does not necessarily correlate with higher pressure increase. Furthermore, the effect of alteration in each parameter in pressure rise is determined. This model is the first numerical step towards understanding the pathogenesis of complications resulting from a fully obstructed CBD and deformation of the CBD in general.
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Authors
M. Baghaei
Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran
M. Kavian
Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran
S. Ghodsi
Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran
S. E. Razavi
Faculty of Mechanical Engineering, University of Tabriz, Tabriz, Iran