Prevalence Oncogenic Human Papillomavirus in Cervical Cancer Patients in Riau Province Indonesia

Background: Cervical cancer is the fourth most deadly cancer in the world, and it is caused by infection of high-risk subtypes of Human PapillomaVirus (HPV) in most cases. The aims of this study were to determine the prevalence oncogenic HPV in cervical cancer patients in Riau Province Indonesia and to determine the clinical manifestation of HPV in cervical cancer patients in Riau Province Indonesia. Methods: This research was a descriptive study conducted at Arifin Achmad General Hospital Riau from February to August ۲۰۱۸ which aimed to analyze HPV genotype prevalence oncogenic of cervical cancer patients. Results: This study showed out ۸۶ of ۱۱۰ women (۷۸.۱%) were found HPV positive, and the most common genotype of HPV was HPV ۱۶ (۳۸.۲%). The average age of cervical cancer patient was ۵۰ years old, and the average number of parities was ۴ times. The majority of participants were married at the age before ۲۰ years (۷۷.۳%) and had low educational background (۶۴.۵%). Vaginal bleeding happened in more than half of the participant as major clinical manifestation (۷۲.۷%), followed by fluor albus (۷۲.۷%), pelvic pain (۶۰.۲%) and fatigue (۶۵.۹%). Conclusions: The most common HPV genotype in Riau Province was HPV type ۱۶ and the most common clinical symptoms of cervical cancer patient were vaginal bleeding, fluor albus, pelvic pain and fatigue.

Keywords:

Cervical cancer , Clinical manifestations Human Papilomavirus , Human Papilomavirus genotype prevalence.