Synthesis and crystallization procedure of piperidin-۴-one and its derivatives: An update

Piperidine is a heterocyclic chemical molecule that is forming by hydrogenating pyridine. In natural and pharmaceutically active drugs, the piperidine ring is an essential molecular component. Several crystal structures of piperidine-۴-ones and their derivatives are reported for their medicinal value. While several methods of piperidin-۴-one crystallization have been developed to obtain a crystal structure, novel approaches are still needed. A review of the synthesis and crystallization procedure of piperidin-۴-ones and its derivatives is outlined in this review paper.

Keywords:

Piperidin-۴-ones , ۲ , ۶-disubstituted piperidin-۴-ones , Recrystallization , Chair conformation , Boat conformation