Effect of multi-epitope derived from HIV-۱ on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_IJBMS-25-2_004

تاریخ نمایه سازی: 30 بهمن 1400

Abstract:

Objective(s): Sleep deprivation (SD) has a negative impact on cognitive functions including learning and memory. Many studies have shown that rapid-eye-movement (REM) SD also disrupts memory performance. In this study, we aimed to investigate the effect of multi-epitope Gag-Pol-Env-Tat derived from Human immunodeficiency virus ۱ (HIV-۱) on REM SD-induced spatial memory impairment with respect to the levels of interleukin-۴ (IL-۴), interleukin-۱۷ (IL-۱۷), interferon-gamma (IFN-γ), immunoglobulin G۱ (IgG۱), immunoglobulin G۲a (IgG۲a), and lymphocyte proliferation in NMRI mice. We used multi-epitope Gag-Pol-Env-Tat derived from HIV-۱ because Gag-Pol-Env-Tat immunogen sequence is one of the most sensitive immunogen sequences of HIV-۱ that can significantly augment cellular and humoral immune systems, leading to the improvement of cognitive functions. Materials and Methods: Morris water maze apparatus was used to assess spatial memory, and multi-platform apparatus was used to induce RSD for ۲۴ hr. Multi-epitope derived from HIV-۱ was subcutaneously injected at the dose of ۲۰ µgr/ml, once and fourteen days before RSD. Results: RSD impaired spatial memory and injection of multi-epitope derived from HIV-۱ reversed this effect. RSD decreased IL-۴, IgG۱, and IgG۲a levels, while multi-epitope derived from HIV-۱ reversed these effects. Multi-epitope derived from HIV-۱ also increased lymphocyte proliferation and decreased IL-۱۷ levels in both control and RSD mice. Conclusion: Multi-epitope derived from HIV-۱ may improve memory performance via induction of anti-inflammatory immune response. 

Authors

Roya Lahimgarzadeh

Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Salar Vaseghi

Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran

Mohammad Nasehi

Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran

Fatemeh Rouhollah

Department of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

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