A review of the role of T cells in different stages of endometriosis

Introduction: Endometriosis is a chronic inflammatory disease in women that is associated with the altered immune response to endometrial cells and facilitates implantation and proliferation of ectopic endometrial tissues. Although T cells play an important role in the immune response and immune disorders, still They are debatable in endometriosis. Also, to date, there is no non-invasive method for diagnosing endometriosis. The purpose of this study is to review the role and importance of T cells in endometriosis.Methods: This study is a review. After searching for the keywords T cell, endometriosis, gynecology from ۲۰۱۵ to ۲۰۲۱, ۳۴ related articles according to the inclusion criteria were extracted from PubMed, Embase, Scopus, and UpToDate databases and analyzed.Results: The findings indicate that in patients with endometriosis, an overall increase in the number of t cells has been observed, indicating the activity of T cells. Suppressive T cells were significantly increased and cytotoxic T was significantly decreased in peritoneal fluid and peripheral blood of women with endometriosis. An increase in T reg and an increase in T-helper activity have also been observed. In women with endometriosis, more T cells expressed Integrin-beta-۱ in women with endometriosis than healthy women. Increased expression of Integrin-beta-۱ may also increase T cell-ECM interactions, which may be responsible for increasing T cell proliferation.Conclusion: T cells play an essential role in the immune response through Tcell mediation and immune disorders. However, the importance of their role in endometriosis is not yet well understood. They play a role in local inflammation and angiogenesis. Therefore, T cell interactions may be involved in the pathogenesis of endometriosis.

Keywords:

T cell , Endometriosis , Gynecology , Immunology