Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients

Background & Objective: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located at chromosome ۱۰. PTEN is a regulator of the PI۳K/AKT signaling pathway that inhibits cell proliferation and promotes apoptosis. PTEN loss of function occurs in a spectrum  of cancers, including colorectal adenocarcinoma. This study aimed to investigate the probable correlation of negative PTEN expression with clinicopathological features and colorectal adenocarcinoma (CRC) patients'''' survival.Methods: In this cross-sectional study using Immunohistochemistry stainingPTEN expression status on ۱۵۱ CRC tissues was evaluated. Then the results of IHC staining was compared to those of clinicopathological features. The relationship between PTEN and KRAS mutation status was also investigated.Results: Of ۱۵۱ CRC samples, ۸۹ (۵۸.۹%) were negative for PTEN expression. Loss of PTEN expression was associated with KRAS mutation (P

Keywords:

Adenocarcinoma , Clinicopathology , Colorectal cancer , PTEN , Prognostic Factors