Correlation of Serum Adiponectin and C-reactive protein with Other Biochemical Parameters in Iraqi Pregnant Women

Adiponectin has anti-inflammatory, insulin-sensitizing and anti-atherogenic properties, while C-reactive protein (CRP) is a systemic inflammation marker. This study was conducted to investigate the relation between adiponectin and CRP with glycemic, lipid profile, liver enzymes, and blood pressure parameters in gestation. Ninety pregnant women were divided into three groups including: Thirty pregnant women in their first trimester (G۱ group), another thirty pregnant women in their third trimester (G۲ group) and thirty non-pregnant women (C or control group). All subjects had been fasting for ten hours before blood samples were drawn. The concentrations of serum adiponectin, serum CRP, fasting plasma glucose, serum insulin, glycated hemoglobin, alanine amine-transferase, aspartate amine-transferase, and blood pressure parameters were assessed. The results showed that serum adiponectin significantly decreased in gestation in G۱ group (p<۰.۰۱) and non- significantly in G۲ group in comparison to the C group. CRP continuously increased from G۱ to G۲ groups (p<۰.۰۱) in comparison to C group. In G۱ group, there was a significant increase in fasting serum insulin. The homeostasis model assessment of insulin resistance (HOMA۲-IR), systolic blood pressure and alanine amine-transferase significantly increased (p<۰.۰۵) in G۱ group compared with C group. The homeostasis model assessment for β cell function (HOMA۲-β) and diastolic blood pressure significantly increased (p<۰.۰۱) in G۱ group in comparison with C group. In G۲ group, BMI, BF %, FSI, HOMA۲-β, HOMA۲-IR, systolic, diastolic blood pressure, and lipid parameters were significantly increased (p<۰.۰۱) in comparison to C group, while aspartate amine-transferase significantly changed (p<۰.۰۵) when compared with C group. This study showed that the early decrease in serum adiponectin and its late correlation with high density lipoprotein might be an adaption mechanism to protect maternal system against high triglycerides level in third trimester.

Keywords:

Adiponectin , CRP , insulin resistance , hyperlepidemia , Maternal adaptions