The Impact of COVID-۱۹ Pandemic on Neuromyelitis Optica Disorder Patients, After one Year
Publish place: Caspian Journal of Neurological Sciences، Vol: 8، Issue: 2
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_CJNS-8-2_006
تاریخ نمایه سازی: 27 فروردین 1401
Abstract:
Background: Coronavirus Disease ۲۰۱۹ (COVID-۱۹) recently created a pandemic with high
mortality. People with underlying diseases are prone to severe infection. The nature of NMOSD
disease and its treatment by immunosuppressants predisposes patients to infection.
Objectives: This study aimed to evaluate the effect of the COVID-۱۹ pandemic on the clinical
course of NMOSD and the characteristics of COVID-۱۹ infection in NMOSD patients.
Materials & Methods: This descriptive study was performed in Isfahan City, Iran, Iran, from
March ۲۰۲۰ to March ۲۰۲۱. We considered relapses during the epidemic and the year before and the
presentation of COVID-۱۹ infection in the patients of NMOSD Clinic of Isfahan Kashani hospital.
Results: The study included ۱۲۰ patients. Their Mean±SD age was ۳۶.۳۷±۹.۶۹ years, and the
mean duration of disease was ۸.۴۹±۵.۳۵ years. Overall, they experienced ۳۶ relapses during the
year before the epidemic (ARR:۰.۳) and ۲۹ during the COVID-۱۹ epidemic (ARR:۰.۲۴). The
maintenance therapy of NMOSD was rituximab in ۹۶ cases, azathioprine in ۲۲, and methotrexate in
۲ ones. ۳۵ patients infected by COVID-۱۹ (based on RT-PCR test). ۶ were admitted to the hospital,
and two patients received ICU care. There was one death due to respiratory failure.
Conclusion: Despite the suppression of the immune system, neither incidence nor the number of
severe complications of COVID-۱۹ infection was high. Therefore, regarding the disabling nature of
NMOSD and the prolonged epidemic period, it may be reasonable to continue the routine treatment
of these patients and train them to stick to health protection instructions.
Keywords:
Authors
Fereshteh Ashtari
Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Science, Isfahan, Iran
Roshanak Mehdipour
Isfahan Neuroscience Research Center, Isfahan University of Medical Science, Isfahan, Iran