Musculoskeletal Manifestations of COVID-۱۹: A Systematic Search and Review

 Coronavirus disease (COVID-۱۹) started its journey around the world from Wuhan, China and gradually became a pandemic.COVID-۱۹ often affects the respiratory system, but symptoms may include fatigue, myalgia, arthralgia, arthritis, and spine andbone pain as presenting complaints. In the present systematic search and review, we aim to highlight the musculoskeletalmanifestations during COVID-۱۹.PubMed Central and Google Scholar search engines were searched for the key words “muscle pain”, “joint pain”, “body ache”,and “fatigue”, in Covid-۱۹ patients.After screening, a total of ۷۶ articles dated between January ۱ and July ۱, ۲۰۲۰ met the inclusion criteria and were included inthe study. All articles were published in English comprising ۳۶,۵۵۸ COVID-۱۹ cases. In cross-sectional studies, fatigue wasfound in ۵۵%, myalgia in ۲۶%, and arthralgia in ۲۰% of cases, respectively. In cohort studies, fatigue was found in ۳۵%, myalgiain ۱۵%, and arthralgia in ۵%, respectively. Sporadic case reports also mention back pain, bone pain, myositis, and arthritis aspresenting symptoms of COVID-۱۹.Fatigue was the most frequent musculoskeletal (MSK) manifestation of COVID-۱۹ followed by myalgia and joint pain. Thefrequency of the different MSK manifestations in COVID-۱۹ may vary widely among different geographic regions.MSK like fatigue, myalgia and arthralgia are frequent symptoms in COVID-۱۹ patients and may vary in different countries.

Keywords:

arthralgia , COVID-۱۹ , fatigue , MSK symptoms , myalgia , Systematic review