Acetic Acid Catalyzed Synthesis of Benzo[h]quinazoline-۲(۳H)-thione Derivatives Using Polyethylene glycol--۴۰۰ as Green Reaction Medium
Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JAOC-2-1_001
تاریخ نمایه سازی: 20 اردیبهشت 1401
Abstract:
In this present investigation, an efficient protocol for the synthesis of bundle of novel substituted benzo[h]quinazoline-۲(۳H)-thione derivatives was reported. The acetic acid catalyzed benzo[h]quinazoline-۲(۳H)-thione derivatives were prepared from ۲-(substituted arylidene)-۱-tetralones, thiourea and green solvent polyethylene glycol-۴۰۰ with efficient and milder reaction condition. All the novel scaffolds were confirmed by the spectroscopic methods (IR, ۱H NMR, Mass and Elemental analysis). The superiority of present method was operational simplicity, easy purification; high yields, easy available catalyst, environmental friendly solvent.
Keywords:
acetic acid , PEG-۴۰۰ , Arylidene-۱-tetralones , Thiourea , Benzo[h]quinazoline- ۲(۳H)-thiones. Green reaction solvent
Authors
Shankaraiah Konda
Department of Chemistry, K. J. Somaiya College, Kopargaon-۴۲۳۶۰۱, (M.S.), India
Sadashiv Nagre
Department of Chemistry, K. J. Somaiya College, Kopargaon-۴۲۳۶۰۱, (M.S.), India
Namdeo Dhokale
Department of Chemistry, K. J. Somaiya College, Kopargaon-۴۲۳۶۰۱, (M.S.), India
Navnath Dalvi
Department of Chemistry, K. J. Somaiya College, Kopargaon-۴۲۳۶۰۱, (M.S.), India
Satish Kale
Department of Chemistry, K. J. Somaiya College, Kopargaon-۴۲۳۶۰۱, (M.S.), India