Ammonium chloride catalyzed Green synthesis, characterization of substituted ۱-H-indazole derivatives

We have demonstrated novel and eco-friendly acceptable green methods for the synthesis of numerous ۱-H-indazole by grinding protocol using NH۴Cl milder acids in an EtOH solvent. The substituted ۱-H-indazole synthesized from the grinding of ortho-hydroxy benzaldehyde with hydrazine hydrate in an Ethanol solvent and NH۴Cl milder acids. The methods give good yield within less time. The protocol is practically green, milder, higher yield, with short reaction times.

Keywords:

۱-H-indazole EtOH , Hydrazine hydrate , NH۴Cl , Grinding