The association of haematological inflammatory markers and psychological function among in COVID-۱۹ patients: A cross-sectional study

Introduction: Due to high inflammation and mental health disorders in Covid-۱۹ patients, we aimed to investigate the relationship between blood inflammatory markers such as WBC, RDW, NLR and PLR and psychological function in COVID-۱۹ patients.Method: The current cross-sectional study and neuro-psychological function and a complete blood count (CBC) were measured on ۱۲۰ COVID-۱۹ patients aged >۳۰ years from the Imam Reza hospital in Mashhad, Iran. Depression, anxiety and stress of participants were evaluated using DASS questionnaire. Also Quality of life, insomnia and sleep quality were measured via SF-۳۶, Insomnia Severity Index and Pittsburgh Sleep Quality Index questionnaire, respectively.Result: No blood parameters were significantly associated with depression, sleep disorders and quality of life (P>۰.۰۵), but in MCHC, WBC and PLR anxiety showed a significant relationship (p<۰.۰۵). In the stress subgroup, only RPR was associated with stress (p<۰.۰۵). In linear regression between hematological parameters and psychological score indicated that RDW and PLR were significantly associated with depression (p=۰.۰۴۵ and ۰.۰۱۶ respectively) and anxiety scores (p=۰.۰۳۸ and ۰.۰۱۰ respectively). PLR was also associated with stress (p=۰.۰۱۲).Conclusion: This study showed a positive association between depression/anxiety/stress symptoms and levels of hematological inflammatory markers including PLR and RDW.

Keywords:

Anxiety , COVID-۱۹ , Depression , Haematological biomarker , Stress