The Risk Factors for Mortality of Adult Inpatients with Covid-۱۹ in Tehran, Iran: A Retrospective Cohort Study

Aims: Considering the importance of mortality management in the control of COVID-۱۹ disease, this study was performed to investigate the risk factors of mortality of adult inpatients with Covid-۱۹ in Tehran, Iran using a retrospective cohort study. Information & Methods: This retrospective cohort study was performed among a random sample of confirmed COVID-۱۹ hospitalized patients, in a main general military hospital in Tehran city (Iran). Laboratory data, clinical sign and symptom, treatment and demographic data were collected and compared between survivors and non-survivors patients. Findings: Among ۳۹۳ patients who contributed in this study, ۳۷ (۹.۴%) with ۹۵% confidence interval (۶.۷% to ۱۲.۷%) died during hospitalization. The result of this study also showed that comorbidity like hypertension and  CHF, vital sign like dyspnea,  RR>۲۴  and Oxygen saturation also laboratory variable like WBC, Lymphocyte, CRP, CR, ESR, , LDH, Sodium, troponin, Procalcitonin in addition lesion type shown the significant relationship with patients death. The findings of this study showed that the use of drug including Kaltra, Vancomycin, Ribavirin, Meropenem, Levofloxasin, and Methyiprednisolon increased the risk of death but use of drug like Azithromycin, Hydroxychloroquin and Naproxen decrease risk of death in COVID-۱۹ hospitalized patients. More results also showed that ARDS, AKI and intubation are the most cause of death among patients. Conclusion: According to the risk factors identified in this study, patients with a higher chance of death can be identified and the necessary treatment measures can be taken to reduce the risk of COVID-۱۹ hospitalized patients.

Keywords:

COVID-۱۹ , Mortality , Pandemic , Risk Factor , Death