Preparation and labeling of HMPAO kit in Iran [Persian]
Publish place: Iranian Journal of Nuclear Medicine، Vol: 8، Issue: 1
Publish Year: 1379
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IRJNM-8-1_007
تاریخ نمایه سازی: 7 تیر 1401
Abstract:
In recent years, several radiopharmaceuticals have been developed for imaging regional cerebral blood flow (rCBF) such as ۷۵Se labelled PIPSE and MOSE, ²º¹TI labelled DDC and ۹۹mTc labelled HMPAO. HMPAO with two asymmetric carbon atoms (At the ۳ and ۹ positions), produces d,۱ and meso isomers, only one of which is retained in the brain. Rapid intracellular conversion of ۹۹mTc-d,۱-HMPAO to hydrophilic ۹۹mTC species causes the complex becoming fixed in the brain. In this report we synthesized and characterized d,۱-HMPAO. Kit formulations have been done and biological characteristics of ۹۹mTc-d,۱-HMPAO have been examined.
Authors
Tayebeh Hadizad
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
Gholamali Shabani
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran
Reza Najafi
Department of Radioisotope, Nuclear Research Center, AOEI, Tehran, Iran